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Chemical Plant Zone may refer to:
- Chemical Plant Zone, the second Zone in Sonic the Hedgehog 2.
- Chemical Plant (Sonic Generations), the second Stage in the console/PC version of Sonic Generations.
- Chemical Plant Zone (Sonic the Comic), the location in Sonic the Comic.
- Chemical Plant Zone (Adventures of Sonic the Hedgehog), the location in the Adventures of Sonic the Hedgehog television series.
- Chemical Plant Zone (Archie), the location in the Archie Comics.