Guardian may refer to:
- The Guardian (Sonic & Knuckles), sub-boss of the Sandopolis Zone in Sonic & Knuckles.
- Guardian (title), the title most commonly given to the echidna protectors of Angel Island.
- Guardian Robot, from Sonic the Comic.
- Gaia Temple guardian, the group from Sonic Unleashed.
- The Guardians, characters from Sonic Underground.