Guardian may refer to:
- The Guardian (Sonic & Knuckles), sub-boss of the Sandopolis Zone in Sonic & Knuckles.
- Guardian (title), the title most commonly given to the echidna protectors of Angel Island.
- Guardian (Archie), the Archie Comics version of the Guardian.
- Guardian (Sonic the Comic), the Sonic the Comic version of the Guardian.
- Guardian Robot, from Sonic the Comic.
- Guardian (Perfection), an object from Sonic the Comic
- Gaia Temple guardian, the group from Sonic Unleashed.
- The Guardians, characters from Sonic Underground.