- Knuckles the Echidna (Archie character) from Archie Comics.
- Knuckles the Echidna (Sonic the Comic) from Sonic the Comic.
- Knuckles the Echidna (Sonic X) from Sonic X.
- Knuckles the Echidna (Sonic Underground) from Sonic Underground.
- Knuckles the Echidna (Sonic the Hedgehog: The Movie) from Sonic the Hedgehog: The Movie.
- Knuckles the Echidna (Sonic Boom) from Sonic Boom.
Alternate Reality Characters
Several alternate reality versions of Knuckles appear in the Archie Comics series:
- Knuckles (Dark Mobius)
- Knuckles the Echidna (Light Mobius), from the alternate reality of Light Mobius.
- Brass Knuckles
- Knuckles, from the Archie zone which most closely follows the games
- Knuckles, a miniseries spin-off to Archie Comics' Sonic comic series.
- Knuckles: The Dark Legion, a second miniseries spin-off
- Knuckles the Echidna, an ongoing comic series, following on from Knuckles: The Dark Legion.
- The Knuckles Knock-Out Special, a one-shot special spin-off of Sonic the Comic, featuring Knuckles and the Chaotix.
- Knuckles' Chaotix, a SEGA 32X game also known as Chaotix, featuring Knuckles the Echidna.
- Knuckles Soccer, an LCD game released by McDonald's.
- Knuckles Baseball
- Knuckles' Treasure Hunt
- Knuckles the Echidna (battle)
- Knuckles the Echidna (Tidal Plant)
- Knuckles the Echidna (Sonic Adventure 2)
- The Knuckles Tribe, a group of Echidnas that had existed since ancient times. Knuckles is a descendant of said tribe.