Mario and Sonic may refer to:
- Mario and Sonic, two video game characters from their respective franchises.
- Mario & Sonic series, a series of cross-over video games starring these characters.
- Mario & Sonic at the Olympic Games, the first official cross-over game between the two characters.
- Mario & Sonic at the Olympic Winter Games, the second title in the Mario & Sonic series.
- Mario & Sonic at the London 2012 Olympic Games, the third title in the Mario & Sonic series.
- Mario & Sonic at the Sochi 2014 Olympic Winter Games, the fourth title in the Mario & Sonic series.
- Mario & Sonic at the Rio 2016 Olympic Games, the fifth title in the Mario & Sonic series.