- For the version of this subject after the Super Genesis Wave, see Neuro-Immuno Deficiency Syndrome (Pre-Super Genesis Wave).
Professor Gerald Robotnik originally intended to find a cure to Neuro-Immuno Deficiency Syndrome to save his granddaughter, Maria. To this end, Gerald agree to lead the United Federation's Project Shadow, seeing the project's immortality research as a potential for a cure. However, the project fell apart when the military shut it down and killed or imprisoned those involved when they deemed the project's result, Shadow, a threat.
- This disease could be based on HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome), a real-life infectious disease.