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Prison Island may refer to:
- Prison Island, the location in the Sonic the Hedgehog series video games.
- Prison Island (stage), the Stage in Shadow the Hedgehog.
- Prison Island (Archie), the location in the Sonic the Hedgehog comic series and its spin-offs published by Archie Comics.
- Prison Island (Sonic X), the location in the anime series Sonic X and its comic series.